SINCE World war 2, medical science has progressed to some stage where competitive medications are around for treat precisely the same ailment in numerous people. It’s not nearly brands (that is a trade issue) but generic drugs (that is a scientific issue). With this report, we shall look at the various factors that decide your selection of a selected drug.

Safety: The following sub-criteria must be considered underneath the criterion of safety:

* Acute therapeutic index: When the patient’s condition is acute, how effective is often a particular drug even though it’s certain side-effects providing the acuteness of the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but come with the possibility side-effect of addiction.

* Long-term safety: medicine may be safe in short-term treatment, but exactly how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case of prolonged use.

* Drug-drug interaction risk: Prescription medication is chemicals, and lots of chemicals reply to make a different chemical, which has an effect that may harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.

Drug-drug interaction risk is of two sorts:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from each other, have certain effects on a single or higher body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is dependent upon for the metabolism. This leads to a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, two or more drugs actually produce the same influence on precisely the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the prescription medication is more intense.

Tolerability: A drug may be effective but not tolerable by all patients. Example: Allergies to certain drugs in most people. Short-term and long-term tolerability have to be considered. Efficacy: A drug isn’t equally efficient at all patients. As an example, some patients with depression or panic attacks experience respite from escitalopram, but there are many that do not, who therefore have to be prescribed an alternative anti-depressant. The interest rate of beginning of therapeutic action is a crucial key to be regarded as too.

Cost: Cost does not necessarily mean the expense of purchase of a specific medicine alone. It will also cover the expense of management of a complication that may arise from utilizing an alternative drug. Example: In a individual that insists on taking alcohol yet should be treated for depression is often administered an SSRI drug since these drugs don’t potentiate the consequences of alcohol, whereas another number of anti-depressants (including tricyclics) might cause a new overuse injury in such patients, which may have to have a various and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram instead of a cheaper tricyclic in this patients.

Simplicity of treatment: The simplest mode of administration is preferred. If you have an option between a shot and oral administration, aforementioned is preferred if your efficacy of the modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are an important factor to determine simplicity of treatment.
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