Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors depending on each SARM’s chemical structure. Because of this, SARMs result in anabolic cellular activity while avoiding most of the negative effects of currently available anabolic steroids. SARMs have already been studied in the treatment of breast cancer and cachexia and have also been utilized as performance-enhancing agents. Here, we evaluate and summarize the present literature on SARMs.
Aim
To give the history, mechanisms, current and potential clinical applications, and also risks and great things about SARMs.
Methods
A literature review was performed in MEDLINE while using the terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancer, benign prostatic hyperplasia, libido, and lean body mass. Both preliminary research and clinical tests were included.
Main Outcome Measure
To perform an assessment peer-reviewed literature.
Results
However, there are currently no U.S. Food and Drug Agency-approved indications for SARMs, investigators are studying the potential uses for these compounds. Preliminary research has devoted to the pharmacokinetics and pharmacodynamics of such agents, demonstrating good availability using a paucity of drug interactions. Early studies have demonstrated potential uses of SARMs inside the management of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and cancers of the breast, with positive results.
Conclusion
SARMs have some of possible clinical applications, with promise for your safe used in the treating cachexia, BPH, hypogonadism, cancer of the breast, and prostate cancer.
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