SINCE Wwii, medical science has progressed to a stage where competitive medications are around for treat the identical ailment in different people. This is not just about brands (the industry trade issue) but generic drugs (the industry scientific issue). With this report, we shall go through the various factors that decide the selection of a certain drug.
Safety: The subsequent sub-criteria should be considered within the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective is really a particular drug even when they have certain side-effects so long as the acuteness with the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but come with the potential side-effect of addiction.
* Long-term safety: medicine might be safe in short-term treatment, but exactly how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and lots of chemicals answer make a different chemical, which has an effect that may harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from each other, have certain effects on one or more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by for the metabolism. This leads to a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually produce the same effect on the identical organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of both prescription medication is more intense.
Tolerability: A medication might be effective and not tolerable by all patients. Example: Allergies to certain drugs in most people. Short-term and long-term tolerability must be considered. Efficacy: A medication is just not equally effective in all patients. For example, some patients with depression or anxiety attacks experience rest from escitalopram, but there are many that do not, who therefore must be prescribed a different anti-depressant. The pace of oncoming of therapeutic action is an important factor to be considered too.
Cost: Cost doesn’t imply the cost of acquiring a specific medicine alone. It will also cover the cost of treating a complication that may arise from using a different drug. Example: Inside a one who insists on taking alcohol nevertheless has to be treated for depression is often administered an SSRI drug because these drugs don’t potentiate the consequences of alcohol, whereas another band of anti-depressants (such as tricyclics) can cause a brand new symptom in such patients, which could need a different and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram rather than cheaper tricyclic in this patients.
Simplicity of treatment: The easiest mode of administration is preferred. If there is an alternative between an injection and oral administration, aforementioned is preferred if the efficacy of both modes is the identical. Or, local application is preferred to the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are key point to determine simplicity of treatment.
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