SINCE Wwii, medical science has progressed to a stage where competitive medications are around to treat precisely the same ailment in various people. This is simply not nearly brands (that is a trade issue) but generic drugs (that is a scientific issue). On this report, we shall glance at the various factors that decide the selection of a specific drug.

Safety: The next sub-criteria should be considered underneath the criterion of safety:

* Acute therapeutic index: If your patient’s condition is acute, how effective can be a particular drug even when it has certain side-effects providing the acuteness in the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but come with the possible side-effect of addiction.

* Long-term safety: drug directory could possibly be safe in short-term treatment, so how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case of prolonged use.

* Drug-drug interaction risk: Medicine is chemicals, and a lot of chemicals answer develop a different chemical, which has an effect that could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.

Drug-drug interaction risk is of two kinds:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of the other person, have certain effects on one or higher body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends upon because of its metabolism. This makes a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, a couple of drugs actually generate the same effect on precisely the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the drugs are more serious.

Tolerability: A medicine could possibly be effective although not tolerable by all patients. Example: Allergies to particular drugs in most people. Short-term and long-term tolerability need to be looked at. Efficacy: A medicine is just not equally good at all patients. As an example, some patients with depression or panic disorders experience relief from escitalopram, but there are numerous that don’t, who therefore need to be prescribed a different anti-depressant. The speed of oncoming of therapeutic action is a the answer to be considered too.

Cost: Cost does not mean the cost of acquisition of a specific medicine alone. It should also cover the cost of management of a complication that could arise from utilizing a different drug. Example: In the individual who insists on taking alcohol but should be treated for depression is generally administered an SSRI drug since these drugs don’t potentiate the results of alcohol, whereas another group of anti-depressants (like tricyclics) may cause a brand new overuse injury in such patients, which would require a different and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram as opposed to a cheaper tricyclic in such patients.

Simplicity of treatment: Most effective mode of administration is preferred. If you have an option between a shot and oral administration, rogues is preferred if the efficacy of the modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are an important factor to choose simple treatment.
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