SINCE World war 2, medical science has progressed with a stage where competitive medications are around to treat exactly the same ailment in various people. This isn’t almost brands (which is a trade issue) but generic drugs (which is a scientific issue). With this report, we shall glance at the various factors that decide your selection of a specific drug.

Safety: The subsequent sub-criteria should be considered within the criterion of safety:

* Acute therapeutic index: If your patient’s condition is acute, how effective is often a particular drug even if they have certain side-effects providing the acuteness of the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but include the possible side-effect of addiction.

* Long-term safety: drug directory might be safe in short-term treatment, but how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in the case of prolonged use.

* Drug-drug interaction risk: Prescription medication is chemicals, and lots of chemicals respond to produce a different chemical, that have an effect that may harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.

Drug-drug interaction risk is of two sorts:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of the other, have certain effects on one or maybe more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends upon for its metabolism. This makes an increase in the side-effects of Lexapro.

· Pharmacodynamic: Here, 2 or more drugs actually produce the same influence on exactly the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both medicine is more serious.

Tolerability: A medicine might be effective but not tolerable by all patients. Example: Allergies to specific drugs in certain people. Short-term and long-term tolerability must be taken into account. Efficacy: A medicine just isn’t equally great at all patients. For instance, some patients with depression or anxiety disorders experience respite from escitalopram, but there are numerous that do not, who therefore must be prescribed some other anti-depressant. The speed of beginning of therapeutic action is a vital the answer to be considered too.

Cost: Cost does not necessarily mean the price tag on acquisition of a certain medicine alone. It will also cover the price tag on management of a complication that may arise while using some other drug. Example: In the person who insists on taking alcohol but should be treated for depression is generally administered an SSRI drug because these drugs don’t potentiate the consequences of alcohol, whereas another gang of anti-depressants (including tricyclics) may cause a new problem in such patients, which may need a different and expensive treatment. Therefore, it’s preferable to prescribe the more expensive escitalopram as opposed to a cheaper tricyclic in this patients.

Simplicity of treatment: The easiest mode of administration is preferred. When there is a choice between an injection and oral administration, the latter is preferred if the efficacy of both modes is the identical. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are an important factor to choose simplicity of treatment.
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