SINCE The second world war, medical science has progressed with a stage where competitive medications are around for treat precisely the same ailment in various people. This is simply not nearly brands (the trade issue) but generic drugs (the scientific issue). On this report, we shall consider the various factors that decide the selection of a specific drug.

Safety: The following sub-criteria must be considered under the criterion of safety:

* Acute therapeutic index: If your patient’s condition is acute, how effective is often a particular drug even when they have certain side-effects provided that the acuteness with the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but come with the opportunity side-effect of addiction.

* Long-term safety: drug directory could be safe in short-term treatment, but exactly how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the case of prolonged use.

* Drug-drug interaction risk: Medicines are chemicals, and lots of chemicals reply to produce a different chemical, that have an effect that may harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.

Drug-drug interaction risk is of two types:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of one another, have certain effects using one or more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is dependent upon for its metabolism. This leads to a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, two or more drugs actually make the same effect on precisely the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both medicine is more intense.

Tolerability: A medicine could be effective and not tolerable by all patients. Example: Allergies to a particular drugs in a few people. Short-term and long-term tolerability need to be taken into account. Efficacy: A medicine just isn’t equally good at all patients. As an example, some patients with depression or anxiety attacks experience respite from escitalopram, but there are numerous that don’t, who therefore need to be prescribed a different anti-depressant. The pace of oncoming of therapeutic action is a factor to be regarded as too.

Cost: Cost does not necessarily mean the price of purchase of a particular medicine alone. It will also cover the price of management of a complication that may arise while using a different drug. Example: In the one who insists on taking alcohol yet should be treated for depression is usually administered an SSRI drug since these drugs don’t potentiate the end results of alcohol, whereas another band of anti-depressants (including tricyclics) can cause a brand new condition in such patients, which may require a various and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram instead of a cheaper tricyclic in such patients.

Simplicity of treatment: Most effective mode of administration is preferred. When there is a choice between an injection and oral administration, the latter is preferred if your efficacy of both modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are an important factor to make a decision simple treatment.
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