SINCE The second world war, medical science has progressed with a stage where competitive medications are around to treat exactly the same ailment in several people. This isn’t nearly brands (which is a trade issue) but generic drugs (which is a scientific issue). In this report, we shall look at the various factors that decide your selection of a selected drug.

Safety: The following sub-criteria should be considered under the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective is often a particular drug even if it’s got certain side-effects provided that the acuteness with the condition is lowered? Example: narcotic pain-killers work well in healing pain but feature the opportunity side-effect of addiction.

* Long-term safety: medicine directory might be safe in short-term treatment, but wait, how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case of prolonged use.

* Drug-drug interaction risk: Medicine is chemicals, and many chemicals answer produce a different chemical, which has an effect that will harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.

Drug-drug interaction risk is of two types:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of the other person, have certain effects using one or even more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by because of its metabolism. This causes more the side-effects of Lexapro.

· Pharmacodynamic: Here, several drugs actually make the same relation to exactly the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both the prescription medication is more serious.

Tolerability: A medication might be effective and not tolerable by all patients. Example: Allergies to particular drugs in certain people. Short-term and long-term tolerability need to be considered. Efficacy: A medication isn’t equally good at all patients. For instance, some patients with depression or panic disorders experience relief from escitalopram, but there are numerous that do not, who therefore need to be prescribed a different anti-depressant. The pace of beginning of therapeutic action is a vital key to be considered too.

Cost: Cost does not mean the price of purchase of a certain medicine alone. It will also cover the price of treatments for a complication that will arise from using a different drug. Example: In the one who insists on taking alcohol nevertheless should be treated for depression is often administered an SSRI drug because these drugs don’t potentiate the effects of alcohol, whereas another gang of anti-depressants (like tricyclics) may cause a brand new condition in such patients, which could require a various and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram rather than a cheaper tricyclic in such patients.

Simplicity of treatment: The simplest mode of administration is preferred. If there is a choice between an injection and oral administration, the second is preferred when the efficacy of both the modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are key point to determine simplicity of treatment.
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